Health & Training · Week of August 27, 2026
Perinatal psychiatry, metabolic and genetic reframings, and the measurement of hidden costs
- ADHD Medication in Pregnancy: Precise Risk Estimates Collide With Uncertain Causal InferenceAn odds ratio of 0.40 for placental abruption, confidence interval 0.29 to 0.57, drawn from 894,986 pregnancies. Stimulants, this says, cut the risk of placental abruption by 60 percent compared to nonstimulants.
- Shared Genetics Across Disorders Undercut Categorical Diagnosis—and Complicate Pregnancy CounselingHere is a sentence a clinician can say to a pregnant patient that is true and still misleads: children exposed to antidepressants in utero show higher rates of autism and ADHD.
- Metabolic Psychiatry Arrives: GLP-1 Drugs and the Challenge to the Neurotransmitter Model"For seven decades, we've really been at this altar of serotonin, norepinephrine and dopamine." That is Roger McIntyre, reportedly professor of psychiatry and pharmacology at the University of Toronto per the JCP podcast…
- Moral Licensing Is an Audience Effect: 115-Experiment Meta-Analysis Points to Reputation, Not ConscienceArticle — "Moral Licensing Is an Audience Effect: 115-Experiment Meta-Analysis Points to Reputation, Not Conscience": Article — "Moral Licensing Is an Audience Effect: 115-Experiment Meta-Analysis Points to Reputation, N…
- The Burnout Paradox: Why Prestige and Purpose Drive Exhaustion Rather Than Prevent ItA tenured theologian could barely drag himself to class. His students, he found, "couldn't care less" about the deeper mysteries of the universe he had built a career around teaching. Years earlier, working as a parking …
Threads we are following
- Whether the continue-versus-cease design becomes the anchor for formal perinatal ADHD guidelines before the precise-looking head-to-head numbers get there first
- Whether biobank-linked polygenic scores can be operationalized into perinatal counseling guidelines that replace categorical diagnosis labels
- Whether ongoing phase III trials show GLP-1 drugs have direct central antidepressant effects independent of weight and glucose changes
- Whether making misconduct as visible as virtue actually suppresses licensing in field settings, not just labs
- Whether distributed-meaning interventions actually lower burnout rates in high-engagement professions when tested longitudinally
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