Longevity Report · Week of September 12, 2026
Sleep as therapy, GLP-1 aging trials, growth hormone reversal, exercise dosing, and nutrition's credibility crisis
- Sleep as an Anti-Aging Target: From CBT-I to Glymphatic Clearance and Sleep-Onset NeuronsNearly three times. That is how much more likely older adults with chronic insomnia were to reach remission when they got cognitive behavioral therapy for insomnia rather than a course on sleep hygiene—and, crucially, th…
- GLP-1 Drugs Enter Human Anti-Aging Trials as Mouse Lifespan Data MountsArticle — "GLP-1 Drugs Enter Human Anti-Aging Trials as Mouse Lifespan Data Mounts": Article — "GLP-1 Drugs Enter Human Anti-Aging Trials as Mouse Lifespan Data Mounts": Two respected longevity scientists looked at the s…
- Nutrition Science's Credibility Crisis: Industry Funding and the Meat/Sugar Guideline FightHere is the contradiction most readers never resolve: the same headlines that call red meat "a significant health risk" also call it "essential for a healthy and balanced diet," and both cite peer-reviewed science publis…
- Beyond Cardio: Combined Aerobic-Plus-Strength Training and the Resistance Sweet Spot for LongevityArticle — "Beyond Cardio: Combined Aerobic-Plus-Strength Training and the Resistance 'Sweet Spot' for Longevity": Article — "Beyond Cardio: Combined Aerobic-Plus-Strength Training and the Resistance 'Sweet Spot' for Long…
- Halting Growth Hormone in Midlife Extends Mouse Lifespan—Against the Supplement Industry's PitchThe last female control mouse died. Four months earlier, the last female mouse whose growth hormone receptor had been torn out at midlife was still alive.
Threads we are following
- Whether pink-noise stimulation improves protein clearance in overnight sleep of older adults, not just fluid flow in young nappers
- Whether any planned trial will include a calorie-restriction arm or male cohort to isolate the mechanism from fat loss and sex
- Whether the January 2026 federal dietary guidelines face review or challenge over undisclosed committee industry ties
- Whether any randomized controlled trial will ever test a specific weekly strength dose against mortality, rather than relying on self-selected observational cohorts.
- Whether anyone runs the proposed pegvisomant aging trial, testing GH receptor blockade in healthy older adults
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