Longevity Report · Week of June 27, 2026
Resistance training dose-response refined, ketone timing unlocks gains, sleep irregularity doubles CVD risk
- Resistance Training's Mortality Benefit: 90-119 Minutes Weekly Shows Maximal ReductionThe Resistance Training Dose: 90 to 119 Minutes
- Post-Exercise Ketone Supplementation Amplifies Endurance Adaptations in Trained CyclistsPost-Exercise Ketones Amplify Endurance Training Benefits
- Sleep Timing Irregularity Doubles Cardiovascular Risk Independent of Duration in Finnish CohortLight voice edit
- VO₂ Max's Central Paradox: Why the Best Mortality Predictor Resists InterventionVO₂ Max's Central Paradox: Why the Best Mortality Predictor Resists Intervention
- Peripheral Immune Checkpoints Offer New Routes to Neurodegeneration Prevention Beyond Blood-Brain BarrierFrontiers of Neurodegeneration Treatment: Targeting the Brain's Border Immune Checkpoints
Threads we are following
- Why does cancer mortality benefit peak at minimal resistance training doses (30-59 minutes) while cardiovascular and neurological protection requires 90-119 minutes?
- Whether post-exercise ketone benefits persist, plateau, or amplify over months or years of sustained use remains unknown
- Whether experimentally reducing bedtime variability lowers cardiovascular events in randomized trials
- Clinical validation of IGFBP7 measurement as a practical biomarker for predicting training response across diverse populations
- U.S. randomized trials of lymphatic-venous anastomosis surgery launching with sham-surgery controls for Alzheimer's and Parkinson's efficacy readouts
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